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4.4.2 Mechanistic hypotheses and clinical positioning Animal studies suggest that GLP-1RAs may restore ovulation by reducing local ovarian lipotoxicity and inflammatory/oxidative stress loads, thereby improving autophagy and PI3K/AKT/mTOR-related imbalances (131)

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As many as 12% of gastric sleeve patients go back for a second surgical procedure because they didnt reach their weight goal with the first, or to manage their weight regain